Sodium Hyaluronate

Hyaluronic acid is a glycosaminoglycan and long-chain polymer of disaccharide units of Na-glucuronate-N-acetylglucosamine and widely exists in all kinds of interstitial substances. In 1934, the hyaluronic acid was separated from bull's eyes by Meyer in USA. In the early years, hyaluronic acid was mainly extracted from the umbilical cords and cock's combs, but now it's by microbial fermentation.

Sodium hyaluronate is well known as natural moisturizing factor and also the polysaccharide compound which human body contains. It has the compatibility and security which other polymeric compounds don't have. It has the physical characteristic of high viscoelasticity and is widely used in body tissue engineering.

Sodium hyaluronate has the thermal instability and its viscosity and molecular weight are easily affected by the change of the pH. Therefore, it must be kept under lower temperature(such as 8℃) and neutral conditions.


Sodium hyaluronate may be extracted from connective tissues of vertebrates, such as cock's combs, eyeballs, umbilical cords, cartilages and so on. It was mainly extracted from cock's combs, but now it is produced by microbial fermentation.

Treptococcus zooepidemicus

Our HA is manufactured by the fermentation of treptococcus zooepidemicus.

In the process of fermentation and purification, raw materials and subsidiary materials are all of Food Grade and Pharmaceutical Grade. Thereinto, peptone is divided into animal one which may have the potential risk of TSE (mainly to Sodium hyaluronate of Pharmaceutical Grade)and botanic one. There are special regulations for the substances which may cause TSE in pharmacopeia, laws and regulations.

The Animal-Free production process flow of Sodium hyaluronate

Production process



Storage condition: Keep in an airtight container and protect from light and humidity under 2-8℃.

Retest date: 2 years

Product display


Aluminum foil bag of Sodium Hyaluronate

Fluoride bottle of Sodium Hyaluronate

Fluoride drum of 1% solution

copyright © 2017 Shandong Topscience Biotech Co., Ltd.

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copyright © 2017 Shandong Topscience Biotech Co., Ltd.

Design By